No. 50: Jon Stryker

Amount donated in 2014: $43.3-million

Beneficiary: Arcus Foundation

Background: Mr. Stryker is an architect and heir to the Stryker Corporation fortune. The medical-products company was founded by his grandfather, Homer Stryker, a surgeon who invented the mobile hospital bed.

Mr. Stryker, 56, gave more than $43.3-million to the Arcus Foundation. He established the philanthropy in 2000 to pursue two grant-making priorities: to combat discrimination against gay, lesbian, bisexual, and transgender people; and to ensure the survival of great apes and their habitats.